CBD and Inflammation

Whether you work in a physically intensive profession, are an athlete, or simply suffer from inflammation of any kind, CBD might be the answer. While it doesn’t work for everybody, most do report that they found relief from inflammation after using CBD. For some, that happened within just a few days. For others, it took weeks or more to feel an effect and find the right CBD oil dosage. Some CBD products aimed at helping with this condition add turmeric (or even better yet, turmeric’s active ingredient, cucuramin) to their formula, as it is a known natural inflammation reliever. Ginger is also a minor alternative health anti-inflammatory player. Most people normally wouldn’t think of inflammation as such a huge health issue. However, chronic inflammation is associated with and may lead to a number of diseases, including cancer, strokes, heart disease, obesity, Chrohn’s disease, and other auto immune diseases such as lupus.

There is an abundence of research and studies which substantially support the powerful role that inflammation itself plays in many conditions and diseases. Moreover, there is also an abundence of research and studies which demonstrate the powerful role that CBD has in modulating the function of the immune system and subsequently significantly reducing inflammation. Research has concluded that this modulation appears to be quite positive and powerful.

In 2011, George W. Booz, Ph.D., FAHA, at the University of Mississippi Medical Center, conduucted an in-depth study on the relationship between CBD and inflammation, which was very conclusive and extensive. His published study is very ineresting and delves beyond CBD’s role in just inflammation (here is the link: George W Booz CBD Inlammation Study) The following was his summary:

“Inflammation and oxidative stress are intimately involved in the genesis of many human diseases. Unraveling that relationship therapeutically has proven challenging, in part because inflammation and oxidative stress “feed off” each other. However, CBD would seem to be a promising starting point for further drug development given its anti-oxidant (although relatively modest) and anti-inflammatory actions on immune cells, such as macrophages and microglia. CBD also has the advantage of not having psychotropic side effects. Studies on models of human diseases support the idea that CBD attenuates inflammation far beyond its antioxidant properties, for example, by targeting inflammation-related intracellular signaling events. The details on how CBD targets inflammatory signaling remain to be defined. The therapeutic utility of CBD is a relatively new area of investigation that portends new discoveries on the interplay between inflammation and oxidative stress, a relationship that underlies tissue and organ damage in many human diseases.”

The fact is that CBD has long been associated with anti-inflammatory and immunosuppressive qualities, but this information had been hushed but is now bursting out into the mainstream. Now, many athletes are wisely ditching their OTC and rx pain medicine and turning to CBD, which has dozens of health benefits, but one of the primary and strongest is combating inflammation. As mentioned, there have been numerous studies on CBD and inflammation and now many athletes swear by the benefits of CBD oil.

We’ll break it down on a molecular level, so it can be easier understood. The two main cannabinoid receptors in your nervous system are CB1 and CB2. While THC is more effective in dealing with the CB1 receptor, controlling appetite, mood, sleep, etc., CBD has an immense impact on the CB2 receptor, which affects the immune system. As inflammation is an immune response, it is extremely important to modulate it and CBD focusing on CB2 has a tremendous impact in reducing inflammation. It is important to note that while CBD is not the only cannabis compound to activate CB2, it is the most abundant and most effective by far. As you can see from the diagram below, the CB2 receptors’ primary role is reducing inflammation in the body.

endocannababinoid system

Many studies have clearly shown that CBD is the strongest of all anti-inflammatory supplements, anti-inflammatory products, and anti-inflammatory medicines. There was one significant study performed on mice at the Imperial College London which showed that CBD demonstrated “powerful anti-inflammatory capabilities“. The researchers found that when the mice received 5mg/kg of CBD, their inflammation was reduced by 50%.

According to one study published out of the Lautenberg Center of General Tumor Immunology in Jerusalem the answer is clear. This study evaluated the effectiveness of CBD when it was isolated compared to when it was combined with the plants more than 80 cannabinoids. The study was conducted on mice and concluded that the whole plant extract in which all of the cannabinoids work synergistically was much more effective in relieving pain and inflammation. Interestingly, the CBD by itself proved in most tests to be ineffective regardless of the dose. In contrast, the effectiveness of the full spectrum CBD continued to increase as the higher doses were given. The tests showed the greatest effectiveness was when the oil was taken orally. It also noted that the medicinal effects and dosages will be unique to each patient. This particular test studied what’s called TNFa, which stands for tumor necrosis factor alpha. When TNFa is present in the body it leads to swelling from fluid in body tissue. So, researchers tested tissue reaction when full spectrum CBD oil was administered and they found it continued to suppress TNFa production to extremely low levels as the dosage was increased.

More encouraging news on CBD for inflammation comes from a 2016 literature review published in BioMed Research International. Researchers cited CBD as a possible key tool in controlling the spread and growth of cancerous cells while noting a strong need for further research. A 2018 article published in Medical News Today demonstrated CBD’s pain relieving and anti-inflammatory effects. Receptors in the brain and immune system are affected by CBD, thus leading to a possible reduction in pain and inflammation. Some researchers are optimistic about how cannabis could assist with the management of inflammatory bowel disease (IBD). Specifically, endocannabinoids may have the ability to create a pathway that turns off the body’s inflammatory response. 

Further, in a 2018 article for Harvard Health Publishing, Dr. Peter Grinspoon discussed prior research on CBD in pain relief in myriad conditions related to inflammation. “CBD may offer an option for treating different types of chronic pain,” he wrote. “A study from the European Journal of Pain showed, using an animal model, CBD applied on the skin could help lower pain and inflammation due to arthritis. Dr. Grinspoon goes on to say, “Another study demonstrated the mechanism by which CBD inhibits inflammatory and neuropathic pain, two of the most difficult types of chronic pain to treat. More study in humans is needed in this area to substantiate the claims of CBD proponents about pain control.”

Inflammation is extremely painful at worst and inconvenient at best. It is also likely a sign that you may be suffering from a serious, acute medical issue. Prescription pain medicine such as opioids, which might provide short-term relief,  have been proven to be disastrous, as the epidemic of addiction looms over society. NSAIDs such as ibuprofen may also provide short-term minimal relief, but those effects are only temporary and are also often accompanied by undesired side-effects, such as ulcers. I have a chronic illness, Crohn’s Disease, which nearly killed me in 2006. After listening to doctors for the first decade and taking medicine such as mercaptopurine also known as 6-MP, which is also a chemotherapy drug. It deteriorated my body and made me worst. Having Crohn’s disease, when I do have other sorts of inflammation, I can only take tylenol as NSAIDs such as ibuprofen can rear Crohns’ ugly head. After taking myself off the 6-MP, which made me tired and nauseous every day, my wife learned about the benefits of CBD oil, which I began taking a few years ago. That it was a turning point or inflection point in my life, as I can honestly say today, that I have never felt healthier, not even 20 years ago, before I was stricken with Crohn’s disease. I swear by CBD oil and my recovery is the sole reason that my wife and I started this informative website, which we hope and pray will lead to others’ recoveries from chronic illnesses, depression, anxiety, addiction, cancer, etc.

***Please write in and tell us your story. We will of course keep your identity private.



The information on this page is based on studies and research as well as experiences from CBD users. For medical condition it is important to consult a licensed healthcare practitioner regarding any potential interacts or complications before consuming a quality CBO product.